biodegradable polymers as drug delivery systems
Smart polymers get into the field to play and take advantage of the molecular recognition and finally produced awareness systems and polymer-carriers to facilitate drug delivery in the body system. Selective drug delivery became one of the most favorable ways to increase the efficacy and safety of chemotherapy. Biodegradable polymers are gaining exponential interest in the field of controlled drug delivery. In the end of the twentieth century, the world entered the era of high-tech and personalized medicine, characterized by the introduction of targeted drugs into clinical practice. Steven Simkevitz, Shape Memory Polymers, 2007. Christine Chan, Drug Delivery Polymers, 2009. Reza Rizvi, Environmental and Biodegradable Polymers, 2009. Nanoparticle-based drug delivery system (DDS) is considered promising for cancer treatment. Joe McRae 7, Vibroacoustics Properties of Foams, 2008. Julia Campbell 9, Polymer/Metals Foams Composites, 2009. Several polymer systems respond to temperature, undergoing a … Linus Leung, Mechanics and Simulation of Bioscaffolds, 2007 Stimuli. Compared with traditional DDS, the nanoparticle-based DDS shows improved efficacy by: 1) increasing half-life of vulnerable drugs and proteins, 2) improving the solubility of hydrophobic drugs, and 3) allowing controlled and targeted release of drugs in diseased site. A promising way to achieve controlled drug delivery is by incorporating the therapeutic agent into the biodegradable polymeric vehicle, releasing the agent continuously as the polymer degrades. Insulin therapy is the central component of treatment for type 1 and advanced type 2 diabetes; however, its narrow therapeutic window is associated with a risk of severe hypoglycemia.
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