anti dsdna anti smith

anti dsdna anti smith

However, rheumatoid factors have modest specificity (~70%) for the disease. 1 doctor answer • 2 doctors weighed in. Anti-Double-Stranded DNA Antibody Tests. The laboratories used anti-dsDNA assay kits from the same sup-plier (Diagnostics Products, Los Angeles, CA); assays were Anti-U1-RNP. These antibody tests are often positive in lupus and can provide support for a diagnosis if the clinical criteria are unclear or if the … CB-CAP - EC4d Erythrocyte-bound C4d is a patented and stable lupus biomarker that measures complement activation to help physicians diagnose lupus and monitor activity. Antinuclear antibody (ANA) Anti-RNP. The panel is composed of the following analytes: Anti-dsDNA, Anti-SSA, Anti-SSB, Anti-Smith, Anti-SmRNP, Anti-RNP, Anti-Chromatin, Anti-Scleroderma, Anti-Centromere B, Anti-Ribosomal P and Anti-Jo-1 (IgG antibodies). HC group tested positive for anti-dsDNA. RNP stands for Antibodies to ribonucleoprotein To check the blood for anti-dsDNA antibodies, a blood sample is required. Anti-SS-B (also called La). Antinuclear antibody ; Anti-RNP. Note: If reflex testing is not desired, order “ANA Screen Only”. Scleroderma 4. Although anti-Smith (Sm) antibody is a highly specific antibody for systemic lupus erythematosus (SLE), the significance of anti-Sm antibody in patients with SLE is unclear. We report a case of PE associated with anti-double-stranded DNA (anti-dsDNA), anti-Smith (anti-Sm), anti-Ro (anti-SSA), and antiribonucleoprotein (anti-RNP) antibodies. Mixed connective tissue disease (MCTD) is a complex, systemic, autoimmune disease generally described as an overlap syndrome. Anti-Smith is negative. The anti-Sm test may be ordered as part of an extractable nuclear antigen (ENA) panel . Sjogren's Anti-SS-A 5.0 High AI 0.0 - 0.9 01 Sjogren's Anti-SS-B 5.0 High AI 0.0 - 0.9 01 Antichromatin Antibodies 0.2 AI 0.0 - 0.9 01 Anti-Jo-1 3.0 High AI 0.0 - 0.9 01 Anti-Centromere B Antibodies 0.2 AI 0.0 - 0.9 01 See below: 01 Autoantibody Disease Association Methods . If results show a 1:40 titer or higher, more specific tests should be performed, including measurement of anti–double-stranded DNA (anti-dsDNA), anti-Smith, anti-RNP, anticardiolipin, and … Other symptoms associated with lupus: Extreme fatigue (tiredness) Headaches Painful or swollen joints Fever Anemia (low numbers of red blood cells or hemoglobin, or low total blood volume) Therefore, if the screen is negative and the dsDNA is indeterminate, the dsDNA result will be reported. This variation could partially be explained by variability of the historical assays, which were done by local laboratories over varying periods of time. Autoimmune tests may include anti-dsDNA, anti-RNP, anti-Smith (or anti-Sm), anti-Sjogren's SSA and SSB, anti-scleroderma or anti-Scl-70, anti-Jo-1, and anti-CCP. Smith Antibody (Anti-Smith) 2. When using HC sera, the ANA titer of ≥ 1:80 and ≥ 1:160 gave a A broad spectrum of autoantibodies was detected in systematic lupus erythematosus (SLE). However, the anti-dsDNA test cannot be used to monitor lupus activity, because anti-dsDNA can be present without any clinical activity. and can be present in anti-dsDNA or anti-Sm negative patients. The ANA screen test software recognizes indeter minate dsDNA results as negative. Antibody tests are a set of blood tests that check for specific antibodies to help clarify the diagnosis of lupus. 3300-100-SMG Human Anti-Smith antigen (Sm) IgG ELISA kit, 96 tests, Quantitative ... increase in anti-dsDNA antibodies > 30 IU/ml in less than 10 weeks in conjunction with a decrease in C4 levels is a reliable indicator of exacerbation of SLE. These antigens are present in subcellular organelles called spliceosomes that are composed of peptide containing small RNAs. The CLIF method is an IF test using a specific substrate, C. Luciliae, that is hemoflagellate. Next: Pathophysiology. Smith antigens are part of the extractable nuclear antigens (ENAs); specifically, they are the proteins that are resistant to ribonuclease. Drug-induced lupus. Yes- my Anti-dsDNA is only a 1, out of a range 0-9. Anti-histone-Ab positive 95% of the time; Make sure to review medications High risk: Procainamide (antiarrhythmic) They attack the body's genetic material, causing cell damage, inflammation, and other destructive effects. We included patients who were tested for anti-Sm antibodies at SLE diagnosis and within … The SLE group included 57 females and 3 males with an average age of 26 years. Also known as: Antibodies to Saline-extracted Antigens; anti-RNP; anti-ribonucleoprotein; anti-SSA; SSA (Ro); anti-Sjögren Syndrome A; anti-SSB; SSB (La); anti-Sjögren Syndrome B; anti-Sm; Smith antibody; Scl-70; anti-topoisomerase; Scleroderma antibodies; anti-Jo-1 Formal name: Extractable Nuclear Antigen Antibodies Related tests: ANA; Autoantibodies; Anti-dsDNA Although anti-Smith (Sm) antibody is a highly specific antibody for systemic lupus erythematosus (SLE), the significance of anti-Sm antibody in patients with SLE is unclear. However, SLE cannot be excluded if anti-dsDNA antibodies are not detected. Anti-nuclear antibodies (ANA), anti-double stranded-DNA (anti-dsDNA), and anti-Smith (anti-Sm) autoantibodies were investigated in 60 Omani patients clinically diagnosed with SLE according to the American College of Rheumatology Criteria. Background: Anti-Smith (Sm) antibody is a highly specific antibody for systemic lupus erythematosus (SLE). Contrary to a widely held belief that anti-ss-DNA Ab occurs frequently in patients with rheumatoid arthritis (RA), anti-ssDNA is present only in 10–15% of this patient population and then at relatively low levels. Anti-Smith IgG (ELISA) Systemic Lupus Erythematosus (SLE) 5-30%4 Anti-Smith antibodies ofer a highly speciic, but comparatively insensitive, clinical marker for SLE. The SLE group included 57 females and 3 males with an average age of 26 years. Data on sensitivity ranges from 25 to 85%. Does this mean I have Lupus? Anti-Smith. $29.00 a very specific marker antibodies for SLE. Anti-dsDNA antibody levels, known as titres, correlate with disease activity in SLE; high levels indicate more active lupus. Anti-DNA – Antibody to native DNA in abnormal titer OR. Other immunological markers should be negative in MCTD, including You anti-double-stranded DNA test, anticentromere test, anti-Scl-70 test, and anti-PM-1 test. Thus, HLA-DR3 appears to be the dominant HLA-D gene that determines the magnitude and quality of the anti-SmD immune response. Anti-Smith (anti-Sm) antibodies are a highly specific autoantibody in SLE, directly against seven Smith proteins that constitute the small nuclear ribonucleoprotein particles [21, 22]. With the oral lesions, your dr was probably thinking lupus and ordered an ANA and Anti-dsDNA. Thanks for your reply! Ab responses correlated with the strength of the T cell responses. CB-CAP - EC4d Erythrocyte bound C4d is a patented and stable lupus biomarker that measures complement activation to help physicians diagnose lupus and monitor activity. The anti-Smith antibody is present in about 20-30% of patients. Anti-SS-B (also called La). Anti-Sm – Presence of antibody to Sm nuclear antigen OR. Anti-dsDNA was positive in all but one (97.8%). Anti-Smith. An anti-dsDNA test may be ordered along with a test for anti-Sm (Smith antibody), another antinuclear autoantibody associated with lupus, to help establish a diagnosis. anti smith anti dsDNA. Exagen provides advanced testing for accurate and timely diagnosis, prognosis and monitoring of rheumatologic autoimmune conditions. polymyositis dermatomyositis. 1. Anti-SS-A (also called Ro). This study aimed to evaluate the association between anti-Sm antibodies and disease activity in patients with new-onset SLE. Anti-Double-Stranded DNA Antibody Tests. As with all the CTDs, the etiology of UCTD is unknown, and the lack of validated classification criteria has complicated the task of elucidating the pathophysiology. Anti Centromere B Antibodies; Anti-dsDNA Antibodies; Anti-Jo-1; RNP Antibodies; Smith Antibodies; Antiscleroderma-70 (Scl) Antibodies; Sjogren's Anti-SS-A; Sjogren's Anti-SS-B; This test can be ordered when someone is having symptoms that are typically associated with autoimmune disorders. Anti-hemidesmosome. In some cases, they show positive VDRL but it should be a false result. If you have several of these antibodies—or have them in high amounts—you may have an autoimmune disease. Anti-centromere. Thanks for your reply! Typically, these drug-induced dsDNA antibody titers are low, and renal involvement is rare. Interestingly, only DR3 mice mounted an anti-dsDNA Ab response. Introduction. Despite the remarkable specificity of anti-Sm antibodies for SLE, the association between anti-Sm antibody level and the clinical manifestation of SLE is still unclear. ANA ELISA assays have been reported to have lower sensitivities than ANA IFA for systemic autoimmune rheumatic diseases (SARD). Other ENA antigens such as Scl-70, Centromere B, Jo-1, and Ribosomal P should not be routinely screened for, but ordered as individual tests as the differential diagnosis dictates. Anti-dsDNA 2. However, a highly specific marker autoantibody for rheumatoid arthritis (RA) has not yet been determined. ... ANA AUTOAB SMITH : ANA AUTOAB SSA . high specificity; Sjögren syndrome : Antinuclear antibody; Rheumatoid factor; Anti-ribonucleoprotein antibodies. Some definitions in a glance: ANA stands for antinuclear antibody. Group 1 was distinct by negative anti-Ro/SSA and anti-La/SSB; group 2 by predominantly high titer ANA ( >1:1280) and nearly all positive anti-Smith and anti-RNP; and group 3 by more commonly negative anti-Smith and anti-RNP and all positive anti-Ro/SSA. This study aimed to evaluate the association between anti-Sm antibodies and disease activity in patients with new-onset SLE. The presence of rheumatoid factors is currently used as a marker for RA. The anti-smith are 0.3 out of a range of 0.0-0.9. However, only about a third of Lupus cases will have positive smith antibodies. Room temperature. Yes- my Anti-dsDNA is only a 1, out of a range 0-9. A positive test result for double-stranded DNA (dsDNA) antibodies is consistent with the diagnosis of systemic lupus erythematosus. Anti-SS-A (also called Ro). Antinuclear, anti-dsDNA, anti-Smith, and anti-phospholipid antibodies were locally measured at each study site using standard clinical laboratory protocols. Objectives . anti-double-stranded DNA (anti-dsDNA), anti-Smith (anti-Sm) and antiphospholipid antibodies, a direct Coombs’ test (in the absence of haemolytic anaemia) and low levels of complement.17SLE diagnostic cri-teria are met if a patient has four or more criteria (at least one clinical and one immunological) or a biopsy-proven nephritis 3300-100-SMG Human Anti-Smith antigen (Sm) IgG ELISA kit, 96 tests, Quantitative ... anti-dsDNA antibodies > 30 IU/ml in less than 10 weeks in conjunction with a decrease in C4 levels is a reliable indicator of exacerbation of SLE. The anti-dsDNA test is also called the anti-DNA test, the antibody to dsDNA test, and the double-stranded DNA antibody test. An anti-double-stranded DNA (anti-dsDNA) test diagnoses lupus. Anti … Minimum Volume. Speckled pattern: anti-RNP, anti-Smith, anti-SmRNP, anti-SSA, anti-SSB Homogeneous pattern: anti-Chromatin, anti-dsDNA Centromere pattern: anti-Centromere Cytoplasmic pattern: anti-Jo-1, anti-Ribosomal P Mixed Pattern: anti-Scl-70 . Anti-Sm (anti-Smith, named for the first patient known to have this antibody) is associated with a speckled ANA pattern and is the antibody seen in most patients who do not have anti-dsDNA. For example, anti-Smith antibody positivity was correlated with positivity for other antibodies (anti-RNP, anti-dsDNA, anti-SSB/La, anti-SSA/Ro) in addition to ACR nephritis and Raynaud’s phenomenon. Anti-Smith (Sm). Jerseygirl, your symptoms and labs could be consistent with seronegative lupus (ANA negative) or possibly a related issue such as mixed connective tissue disease. positive ANA test and lupus. And my ssa is 0.2 and ssb is 1.7 out of a range of 0.0-0.9. Anti-Smith (Sm),.Anti-Smith antibodies are present in some cases of systemic lupus erythematosus (SLE) and mixed connective-tissue disease (MCTD). Myositis/Sjögren’s – anti-SSA. The sensitivity of anti-dsDNA, anti-Sm, and anti-U1 RNP antibodies for the diagnosis of SLE is relatively low, but the specificity of anti-dsDNA and anti-Sm antibodies for SLE makes them invaluable tools to assist in the diagnosis of this disease. Transport Temperature. Treatment of overlapping diseases involves immunosuppression, but the choice of medications is guided by the clinical features in a particular patient and tailored to the most severe or major disease manifestations. Bedside echo if ill or hypotensive; CBC; Chem; Urinalysis; Urine pregnancy; As directed by organ system involved; Drug Induced Lupus. However, only about a third of Lupus cases will have positive smith antibodies. The anti-Sm test may be ordered as part of an extractable nuclear antigen (ENA) panel . < 25 is negative 25 to 34.9 is equivocal 35 to 99.9 is weak positive 100 to 200 is positive > 200 is strong positive BUT your lab may use different reference ranges than my lab, OR your test may have been a different anti-dsDNA test entirely than mine was! Anti-Sm is highly specific for SLE but, like anti-dsDNA, is not sensitive. Anti-acetylcholine receptor. ANA AUTOAB SSB . These antibody tests are often positive in lupus and can provide support for a diagnosis if the clinical criteria are unclear or if … It correlates with disease activity. 76731000: LNC: LP38937-6, LP37936-9, MTHU010623, MTHU002322: English: Double stranded anti DNA antibody, Native deoxyribonucleic acid (DNA) antibody, antibodies dna double stranded, dna ab ds, dsdna ab, antibodies dsdna, antibody dna double strand, dna double strand ab, Double stranded anti-deoxyribonucleic acid antibody (substance), Double stranded anti … CB-CAP – BC4d Goodpasture syndrome. Anti-Smith and Anti-Ribonucleoprotein Antibodies. Anti-Sm antibodies are only present in 15 to 30% of the patients with SLE, but they are highly specific for SLE. But RA factor, anti-centromere B antibodies, anti-dna (ds) qn, anti-jo-1, anti chromatin, anti scleroderma-70, rnp, anti-SSB, and smith antibodies are all normal. Speckled Pattern A. Anti-RNP occurs in patients with SLE, mixed connective tissue disease, and occasionally other systemic autoimmune disorders and systemic sclerosis. Anti-dsDNA and anti-Sm antibodies are clinically thought to be highly specific for SLE. Laboratory abnormalities included: anti-nuclear antibody (Ab), anti-Ro Ab, anti-La Ab, anti-Smith Ab, anti-U1-ribonucleoprotein Ab, anti-rheumatoid factor Ab, anti-dsDNA Ab, low C3, low C4, anti-cardiolipin Ab, lupus anticoagulant and beta2-glycoprotein. An anti-ENA screen determines the levels of seven different autoantibodies including anti-Sm, anti-RNP, anti-SSA, anti-SSB, anti-Jo-1, anti-Scl 70 and anti-CENP-B. Thanks for your reply! Serum samples for anti-dsDNA antibody determinations were collected at least once per month and analyzed by Farr assay at 1 of 2 central laboratories (1 in the US and 1 in Europe). Most of these patients are Asian and African American. Of particular interest, anti-A2/anti-RA33 antibodies are present in early stages of disease in MRL/lpr mice, where they precede anti-dsDNA antibody formation, and in tumor necrosis factor-α transgenic mice (which develop severe erosive arthritis similar to RA) [7, 10]. Anti-SS-A (also called Ro). Smith anti: <0.02. Associated with lupus nephritis; Anti-Sm antibody. Antinuclear, anti-dsDNA, anti-Smith, and anti-phospholipid antibodies were locally measured at each study site using standard clinical laboratory protocols. just got the resukts of ANA test and only got the following: ANA 160 ANA pattern homogeneous No symptoms age 65 female – all other blood tests normal Do I have Lupus? Anti-double stranded DNA (anti-dsDNA) antibodies are a useful tool for the diagnosis of systemic lupus erythematosus (SLE) , and represent one of the criteria of the American College of Rheumatology (ACR) for the classification of SLE. This study aimed to evaluate the association between anti-Sm antibodies and disease activity in patients with new-onset SLE. Some patients have both anti-dsDNA and anti-Sm. Anti-Ro, La, RNP, Smith and anti-dsDNA antibodies had substantial agreement over time, while complement had less agreement. Autoantibodies are proven useful diagnostic tools for a variety of rheumatic and non-rheumatic autoimmune disorders. The highest correlation was between anti-Smith and anti-RNP antibodies (correlation coefficient 0.6361). The anti-smith are 0.3 out of a range of 0.0-0.9. However, case 9, 12 and 7 in the MMP group tested positive for anti-dsDNA, with a titer of 1:10, 1:20 and 1:40, respectively, as shown in Table 5. A renal biopsy was performed. Anti-SMith: Anti-SM is specific to Lupus. And my ssa is 0.2 and ssb is 1.7 out of a range of 0.0-0.9. Anti-nuclear antibodies (ANA), anti-double stranded-DNA (anti-dsDNA), and anti-Smith (anti-Sm) autoantibodies were investigated in 60 Omani patients clinically diagnosed with SLE according to the American College of Rheumatology Criteria. 1 49 F C - RT PCR Cough No HCQ, Zinc LN, pleuritis, anaemia, lymphopenia, SS ANA,anti- dsDNA,anti- Smith,anti- RNPA CA,, hypocomplementemia Azathioprine, prednisone (5 mg/day) Obese (BMI 40) 2 48 F H Rapid antigen SOB, diarrhoea Yes Oxygen, convalescent plasma, azithromycin LN, neuropsychiatric lupus, APLS ANA,anti- dsDNA,anti- SSA,A CA, anti–double-stranded DNA (anti-dsDNA), anti-Smith, anti-RNP, anticardiolipin, and beta-2 gly-coprotein antibodies and lupus anticoagu-lant; elevated levels of one or more of these ... often in association with other lupus-associated autoantibodies such as anti-Sm (anti Smith … Double-stranded DNA (dsDNA) IgG antibodies are part of the American College of Rheumatology criteria for the diagnosis of systemic lupus erythematosus (SLE). W … Anti-dsDNA Test Results. – Anti-Smith – Anti-dsDNA (by ELISA and confirmation by Crithidia) – ANA (by ELISA and IIF) Extractable Nuclear Antigens Antibodies associated with autoimmune conditions that cause lupus-like symptoms: – Anti-SS-A/Ro – Anti-SS-B/La – Anti-Scl-70 – Anti-U1RNP – Anti-RNP70 – Anti-CENP – Anti-Jo-1. Despite the remarkable specificity of anti-Sm antibodies for SLE, the association between anti-Sm antibody level and the clinical manifestation of SLE is still unclear. Anti-desmoglein (Anti-desmosome) Bullous pemphigoid. One of the ACR Criteria for SLE diagnosis. People with lupus often have an antibody in the blood called anti-double-stranded DNA, also known as anti-dsDNA. They are a very specific marker for the disease, with some studies quoting nearly 100%. Anti-Smith (Sm). and Laboratory Medicine anti-Smith (referred to as anti-Sm) antibody; biopsy-proven kidney disease; biopsy-proven skin disease combined with another symptom; Doctors have difficulty agreeing on a standard definition for individual patients (diagnostic criteria) because many organs can be involved and they can be involved in different ways. Anti-double stranded DNA (Anti-dsDNA) antibodies are a group of anti-nuclear antibodies (ANA) the target antigen of which is double stranded DNA.Blood tests such as enzyme-linked immunosorbent assay (ELISA) and immunofluorescence are routinely performed to detect anti-dsDNA antibodies in diagnostic laboratories. Preferred Specimen(s) 1 mL serum. A 32-year-old male asked: Pain on activities all over body Ana pro ra factor tsh nuclear bone scan normal rheumo thinks its due to past chronic vit d def. Anti-RNP. These antibody tests are often positive in lupus and can provide support for a diagnosis if the clinical criteria are unclear or if the … Anti-Ro (anti-SSA) and anti-La (anti-SSB) are seen in 40% of SLE patients, but have a stronger association with Sjogren’s syndrome. Reference Range * ... (La), Smith, SmRNP, and RNP. The anti-smith are 0.3 out of a range of 0.0-0.9. sle mixed connective tissue disease. Anti-dsDNA antibodies and complement components (C3 and C4) may be used to monitor SLE activity, especially in Methods . Smith Antibody (Anti-Smith or Anti-Sm) Positive in 20-30% of SLE cases; Highly specific for SLE (nearly pathognomonic) Does not correlate with disease activity (unlike Anti-dsDNA) Double Stranded DNA Antibody . We included patients who were tested for anti-Sm antibodies at SLE diagnosis and within … The presence of anti-dsDNA antibodies suggests more serious lupus, especially lupus nephritis (kidney lupus). Anti-Smith (Sm). Therefore, anti-ENA antibodies are directed against components that can be extracted from the cell nuclei of collagen-rich tissue. Search the Healthwise Knowledgebase . For example, anti-Smith antibody positivity was correlated with positivity for other antibodies (anti-RNP, anti-dsDNA, anti-SSB/ La, anti-SSA/Ro) in addition to ACR nephritis and Raynaud’s phenomenon. Antinuclear antibody ; Anti-RNP. with mixed connective tissue disease. CB-CAP – BC4d When a person's immune system mistakes healthy tissue for a foreign invader, autoantibodies are produced. Anti-Smith (Sm). So really, the ssb is the only high one. Anti-dsDNA with confirmation by Crithidia. If you test positive for ANA, your NYU Langone rheumatologist may order tests for anti-double-stranded DNA, anti-SSA/RO, and anti-Smith antibodies to get more detailed information. I was just trying to understand if the others, although not positive, are a bad sign. Department of Pathology . YES +anti-dsDNA +anti-ssDNA +anti-RNP +anti-Smith +anti-SSA 3day pulse- dose steroids, IV 500mg/day methylprednisolone Return to baseline 1year after insult 3[8, 10] 14yo/F HA 1 mo, progressive vomiting 1week, abducens palsy 5days YES NO CT: Diffuse white matter hypodensity without ventricular dilatation. The patient now also has clinical findings (sclerodacytly, Raynaud phenomenon, finger-tip ulcerations) consistent with scleroderma overlap. Anti-dsDNA antibody. Antinuclear antibody ; Anti-RNP. Objectives . It could be MCTD, Mixed Connective Tissue Disease. Antinuclear antibodies are associated with many different autoimmune disorders. Group 1 was distinct by negative anti-Ro/SSA and anti-La/SSB; group 2 by predominantly high titer ANA ( >1:1280) and nearly all positive anti-Smith and anti-RNP; and group 3 by more commonly negative anti-Smith and anti-RNP and all positive anti-Ro/SSA. Anti-Scl-70 antibodies are linked to. Anti-Smith. C3 and C4 complement levels were normal. View Notes - Lumabas sa boards pag march 2019.docx from BIO 1 at Cebu Doctors' University - Mandaue City. anti nRNP antibody is found in. If it is positive, then this means that there are autoantibodies present within the blood. Anti-Sm antibody binds to a protein that is attached to DNA. autoimmune hepatitis) or infections as well as in clinically healthy persons. highest specificity; Anti-cardiolipin; Lupus anticoagulant; Antiphospholipid syndrome : Anti-β 2 glycoprotein; Anti-cardiolipin; Lupus anticoagulant; Drug-induced lupus : Anti-histone. Normal now vitd wt? We evaluated the demographic, clinical, laboratory, and therapeutical features of a monocentric SLE cohort according to the anti-dsDNA status. study of 794 subjects comprising 304 SLE patients, 285 patients with other rheumatic diseases and 205 normal healthy controls, positivity for Tier 1 markers (anti-dsDNA, confirmed using Crithidia, anti-Sm or elevated EC4d and BC4d) was associated with a sensitivity of 46% and a specificity of 97%. There is evidence that anti-ssDNA, like anti-dsDNA, is involved in the pathogenesis of lupus nephritis. They offer several panels with a wide array of autoimmune markers. Anti-SS-B (also called La). 85% of people in the latter group develop SLE within 5 years of initial detection of anti-dsDNA. 2. This laboratory test is available in 4 online lab test stores. Anti-RNP: RNP is positive for almost all cases of Mixed Connective Tissue Disease (MCTF). Antisynthetase syndrome – anti-Jo-1. Serologic tests revealed positive RF and negative ANA, anti-dsDNA, anti-Smith, anti-ribonucleoprotein, anti-myeloperoxidase, and anti-proteinase 3 antibodies. The tests used to detect anti-dsDNA include the enzyme-linked immunosorbent assay (ELISA), the Crithidia luciliae immunofluorescence test, and radioimmunoassay. The sensitivity and specificity of ANA and anti-dsDNA are shown in Table 6. Anti-ssDNA 3. So really, the ssb is the only high one. Contrary to a widely held belief that anti-ss-DNA Ab occurs frequently in patients with rheumatoid arthritis (RA), anti-ssDNA is present only in 10–15% of this patient population and then at relatively low levels. Antinuclear antibody ; Anti-RNP.

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